Pruritus Therapeutics Are Effective In Reducing The Release Of Histamine And Treating Itch Or Dermatitis

Pruritus Therapeutics

Pruritus Therapeutics is the process of treating itch or dermatitis. It is the most common symptom associated with diseases and disorders of the skin and can be extremely debilitating. The pathophysiology of pruritus is complex, and antipruritic therapy may be directed against a number of targets, including the epidermal barrier, immune system or nervous system. The management of itch is usually a combination of drug treatment and other measures, including avoidance, reassurance and topical therapies.

A detailed history and physical examination should be performed to identify any possible underlying cause. This will help in instituting a targeted treatment plan and will improve outcomes as pruritus usually resolves upon exclusion of the underlying disorder. Topical therapies are the mainstay of therapy for mild and localized itch as it is generally not responsive to systemic agents.

Several anti-itch drugs are available for the Pruritus Therapeutics, most commonly corticosteroids and antihistamines. They are effective in reducing the release of histamine, an important mediator of itch. However, the effectiveness of these drugs is limited by their side effects, such as atrophogenesis and glare, and their short duration of action. Many patients do not respond to these drugs.

Severe and persistent itch often leads to secondary lesions such as erythema, erosions, excoriations and crusts. This can also lead to skin infections that can develop into folliculitis, abscess and erysipelas. A severe and persistent itch can affect sleep, appetite and mood.

There is a significant need for new drugs to treat pruritus, and the current pipeline includes compounds with a variety of mechanisms. These include inhibitors of the HDAC, MAPK and NMDA receptors and compounds that target histamine and mast cell activation. There are a number of experimental neuropeptides with potential antipruritic activity.

MC2 Therapeutics and EPI Health, LLC, announced their partnership in August 2020, for marketing WYNZORA Cream in the US. EPI Health LLC is a leading pharmaceutical company in the dermatological industry

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